Storm water flooding and thermal stress are two important issues for most of the developed area in cities. Due to the climate change, these two issues may contribute to serious problems in dense urban areas. Therefore, the sectors for public health and disaster management should be able to assess the vulnerability to storm water flooding and thermal stress. To achieve this goal, two cities in different climate regions with various urban context have been selected as the pilot areas, i.e., Tainan, Taiwan and Groningen, Netherlands.